| Review Article |
| Efficacy of Bisphosphonate in Patients with Neurofibromatosis Type 1 |
| Arzu Jalilova, Alessandra Cocca |
| DOI: https://doi.org/10.11005/jbm.24.809 |
 | This review aims to synthesize current knowledge regarding the use of bisphosphonates (BPs) in the treatment of bone complications in patients with neurofibromatosis type 1 (NF1). NF1 is a genetic disorder marked by multiple benign tumors of the nervous system and various skeletal abnormalities, such as osteoporosis and an increased risk of fractures. BPs are drugs that inhibit bone resorption,... |
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| Original Articles |
| Transforming Growth Factor-β Signaling Inhibits the Osteogenic Differentiation of Mesenchymal Stem Cells via Activation of Wnt/β-Catenin Pathway |
| Mahsa Tahoori, Azita Parvaneh Tafreshi, Fatemeh Naghshnejad, Bahman Zeynali |
| DOI: https://doi.org/10.11005/jbm.24.761 |
 | Background: Due to the contradictory and temporally variable effects of transforming growth factor-β (TGF-β) and the Wnt/β-catenin pathways on osteogenic differentiation in different stem cell types, we sought to examine the activity of these pathways as well as their interaction during the osteogenic differentiation of the osteo-induced adiposederived mesenchymal stem cells (AD-MSCs). Methods: The osteo-induced AD-MSCs were treated with TGF-β1... |
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| Pharmacogenetics of Response to Bisphosphonate Treatment in Postmenopausal Osteoporosis: A Prospective Study |
| Sirin Akbulut Ayturk, Ozden Ozyemisci Taskiran, Ebru Koseoglu Tohma, Aylin Sepici Dincel, Nesrin Demirsoy, Vesile Sepici |
| DOI: https://doi.org/10.11005/jbm.24.787 |
 | Background: This study aims to investigate the effect of genetic polymorphisms of vitamin D receptor (VDR), estrogen receptor 1 (ER1), and Col1a1 on the response to bisphosphonate (BP) therapy in women with postmenopausal osteoporosis (OP). Methods: Twenty-one women with postmenopausal OP who received alendronate, ibandronate, or zoledronic acid for one year were enrolled in this study. Bone mineral density (BMD)... |
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| Generate Quantitative Computed Tomography-Equivalent Computed Tomography Image Interpretation Reports in Patients with Spinal Deformities |
| Hyunbin Kim, Hyeon Su Kim, Shinjune Kim, Jun-Il Yoo |
| DOI: https://doi.org/10.11005/jbm.24.801 |
 | Background: Quantitative computed tomography (QCT) is essential for assessing osteoporosis and monitoring spinal deformities. “Clari-QCT,” a software that uses artificial intelligence to analyze conventional computed tomography (CT) scans and produce QCTequivalent reports. This study aims to evaluate the effectiveness of Clari-QCT by comparing its results with traditional QCT, with the goal of validating new diagnostic tools for spinal deformities. Methods:... |
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| Incidence of Hypercalcemia and Vertebral Fractures Following Denosumab Withdrawal in Lung Cancer Patients: A Longitudinal Cohort Study |
| Marta Villanova, Sharon H. Chou, Le Min |
| DOI: https://doi.org/10.11005/jbm.24.803 |
 | Background: Bone-target agents (BTAs), including denosumab (DMAb), are one of the bone metastasis treatments that should continue indefinitely. However, BTAs may be interrupted in some cases. In osteoporosis, DMAb withdrawal causes a rebound effect characterized by an increased bone turnover with spine fractures and hypercalcemia; evidence of the DMAb withdrawal effect in oncology is lacking. Methods: This study aimed to... |
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| Treatment Goals for Prevention of Vertebral Fractures in Patients with Rheumatoid Arthritis |
| Takeshi Mochizuki, Mari Ando, Koichiro Yano, Ryo Hiroshima, Katsunori Ikari, Ken Okazaki |
| DOI: https://doi.org/10.11005/jbm.24.811 |
 | Background: Patients with rheumatoid arthritis (RA) are at an increased risk of osteoporosis and vertebral fractures. This study aimed to investigate factors associated with vertebral fractures and treatment goals to prevent new vertebral fractures in patients with RA. Methods: The database used in this study included outpatient data of RA patients at the authors’ hospital of RA patients taken from... |
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| Twenty-Year Trends in Osteoporosis Treatment and Post-Fracture Care in South Korea: A Nationwide Study |
| Kyoung Jin Kim, Kyoung Min Kim, Young-Kyun Lee, Jihye Kim, Hoyeon Jang, Jaiyong Kim, Ha Young Kim |
| DOI: https://doi.org/10.11005/jbm.24.829 |
 | Background: Osteoporosis is a significant public health issue in aging populations. Despite advances in pharmacotherapy, underdiagnosis and undertreatment remain prevalent even in patients with recent fractures. This study examined 20-year trends (2002– 2022) in anti-osteoporotic medication (AOM) usage in South Korea. Methods: Data from the Korean National Health Information Database were retrospectively analyzed. The study included individuals aged ≥50 years... |
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| Letter to the Editor |
| Calcium Supplementation: To Do or Not to Do |
| Emanuella Graciela Borges Fonseca, Carlos Marques dos Santos, Felipe Freire da Silva, Ana Tereza Amoedo Martinez, Jozélio Freire de Carvalho |
| DOI: https://doi.org/10.11005/jbm.24.775 |
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